Irinotecan HCl Trihydrate , ≥98% , 136572-09-3

CAS NO.：136572-09-3

Empirical Formula: C33H45ClN4O9

Molecular Weight: 677.18

MDL number: MFCD01765731

EINECS: 603-967-2

PRODUCT Properties

• Melting point: 250-256°C (dec.)
• Boiling point: 257°C(lit.)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
• form: White solid.
• color: Yellow
• Water Solubility: Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
• Merck: 14,5091
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
• InChIKey: KLEAIHJJLUAXIQ-VRWBIZLENA-N
• SMILES: N1(C2CCN(C(OC3C=CC4C(C=3)=C(CC)C3CN5C(C=3N=4)=CC3[C@](CC)(O)C(=O)OCC=3C5=O)=O)CC2)CCCCC1.[H]Cl.[H]O[H].[H]O[H].[H]O[H] |&1:24,r|
• CAS DataBase Reference: 136572-09-3(CAS DataBase Reference)

Description and Uses

Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3

Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H372
• Precautionary statements: P260-P264b-P270-P301+P312-P314-P330-P403-P501c
• Risk Statements: 22
• Safety Statements: 20/21-22
• RTECS: DW1060750
• HS Code: 29349990
• Toxicity: dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.