Ivabradine HCl , ≥98% , 148849-67-6

Synonym(s):
3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

CAS NO.：148849-67-6

Empirical Formula: C27H36N2O5.HCl

Molecular Weight: 505.05

MDL number: MFCD00929899

EINECS: 638-798-3

PRODUCT Properties

• Melting point: 193-196?C
• alpha: 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
• storage temp.: 2-8°C
• solubility: H2O: ≥5mg/mL (warmed)
• form: powder
• color: white to beige
• optical activity: [α]/D +5 to +9°, c = 1 in DMSO
• Water Solubility: H2O: ≥5mg/mL (warmed)
• Merck: 14,5247
• InChIKey: HLUKNZUABFFNQS-ZMBIFBSDSA-N
• SMILES: C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
• CAS DataBase Reference: 148849-67-6(CAS DataBase Reference)

Description and Uses

In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .

angina therapeutic

Safety

• Symbol(GHS): GHS09
• Signal word: Warning
• Hazard statements: H400
• Precautionary statements: P273
• Hazard Codes: N
• Risk Statements: 50/53
• Safety Statements: 60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• HS Code: 2933.79.1500