3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine , 97% , 151266-23-8

CAS NO.：151266-23-8

Empirical Formula: C5H4IN5

Molecular Weight: 261.02

MDL number: MFCD03787931

PRODUCT Properties

• Boiling point: 312.3±52.0 °C(Predicted)
• Density: 2.92±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• form: powder to crystal
• pka: 10.50±0.20(Predicted)
• color: White to Light yellow to Light orange
• Sensitive: Light Sensitive
• λmax: 282nm(lit.)
• InChI: InChI=1S/C5H4IN5/c6-3-2-4(7)8-1-9-5(2)11-10-3/h1H,(H3,7,8,9,10,11)
• InChIKey: HQAIUXZORKJOJY-UHFFFAOYSA-N
• SMILES: C1=NC(N)=C2C(I)=NNC2=N1

Description and Uses

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a key intermediate in the synthesis of ibrutinib.

3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H335-H315-H319
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xn
• Risk Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-37
• TSCA: N
• HS Code: 29335990