Irsogladine Maleate , ≥98.0%(HPLC) , 84504-69-8

CAS NO.：84504-69-8

Empirical Formula: C13H11Cl2N5O4

Molecular Weight: 372.16

MDL number: MFCD00873566

PRODUCT Properties

• Melting point: 181-182°C
• storage temp.: Inert atmosphere,Room Temperature
• Water Solubility: Insoluble in water
• solubility: DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM); DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM); DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM)
• form: White crystalline powder.
• color: White to Almost white
• Merck: 14,5102
• InChI: InChI=1S/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: PJLVTVAIERNDEQ-BTJKTKAUSA-N
• SMILES: N1=C(C2=CC(Cl)=CC=C2Cl)N=C(N)N=C1N.C(O)(=O)/C=C\C(O)=O
• CAS DataBase Reference: 84504-69-8(CAS DataBase Reference)

Description and Uses

Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .

An anti-ulcer drug. Potent PDE4 inhibitor

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361
• Precautionary statements: P201-P202-P281-P308+P313-P405-P501
• WGK Germany: WGK 3
• RTECS: XY5930000
• HS Code: 2933.69.6050
• Storage Class: 11 - Combustible Solids
• Toxicity: LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)