Ketanserin Tartrate , 98% , 83846-83-7
Synonym(s):
3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt;5-HT 2A Serotonin Receptor Antagonist, Ketanserin, R 41 468;Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem;R 41468 (+)-tartrate salt
CAS NO.：83846-83-7
Empirical Formula: C26H28FN3O9
Molecular Weight: 545.52
MDL number: MFCD00084651
EINECS: 281-062-8
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB143.20 | In Stock |
|
| 50MG | RMB359.20 | In Stock |
|
| 250MG | RMB599.20 | In Stock |
|
| 1g | RMB1599.20 | In Stock |
|
| 5g | RMB3679.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 183～186℃ |
| storage temp. | 2-8°C |
| solubility | ethanol: 3.3mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble to 10 mM in water |
| InChIKey | KMTLTEVOQLMYRS-LREBCSMRSA-N |
| SMILES | O[C@H]([C@@H](O)C(O)=O)C(O)=O.Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=O)Nc4ccccc4C3=O |
| CAS DataBase Reference | 83846-83-7(CAS DataBase Reference) |
Description and Uses
Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). It has no activity at 5-HT1 receptors but does have activity at histamine type 1, α1-adrenergic, and dopamine receptors with Ki values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.
Selective 5-HT2A serotonin receptor antagonist
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | VA1411195 |
| HazardClass | 6.1 |
| HS Code | 29335990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
| Toxicity | LD50 oral in rat: 129mg/kg |
