Ketotifen Fumarate , 99% , 34580-14-8

Synonym(s):
Ketotifen fumarate salt

CAS NO.：34580-14-8

Empirical Formula: C23H23NO5S

Molecular Weight: 425.5

MDL number: MFCD00079394

EINECS: 252-100-0

PRODUCT Properties

• Melting point: 192 C
• storage temp.: 2-8°C
• solubility: Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in acetonitrile.
• form: Solid
• color: White to Pale Beige
• PH: pH (10g/l, 25℃) : 3.0～4.0
• Water Solubility: Soluble in water (10 mg/ml), DMSO (100 mM), and methanol.
• λmax: 297nm(MeOH)(lit.)
• Merck: 14,5307
• InChIKey: YNQQEYBLVYAWNX-WLHGVMLRSA-N
• SMILES: C1(=C2/CCN(C)CC/2)\C2=C(C=CC=C2)CC(=O)C2SC=CC\1=2.C(/C(=O)O)=C\C(=O)O
• CAS DataBase Reference: 34580-14-8(CAS DataBase Reference)

Description and Uses

Ketotifen is a histamine H₁ receptor antagonist (K_i = 1.3 nM) and mast cell stabilizer. It is selective for H₁ receptors over H₂ and H₃ receptors (K_is = 987 and 2,500 nM, respectively). Ketotifen (50 and 100 μM) inhibits degranulation of rat peritoneal mast cells induced by compound 48/80 . It inhibits the passive cutaneous anaphylaxis (PCA) reaction in rats by 54.6% when administered orally at a dose of 20 mg/kg. Ketotifen (30 mg/kg) inhibits the quick phase airway response in a rat ovalbumin-induced immediate airway response model. Formulations containing ketotifen have been used in the treatment of itching associated with allergic conjunctivitis.

Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H319
• Precautionary statements: P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
• Hazard Codes: Xn,T
• Risk Statements: 22-36/37/38-23/24/25
• Safety Statements: 36-45-36/37/39-26
• WGK Germany: 3
• RTECS: DE8260000
• HS Code: 29349990
• Toxicity: child,TDLo,oral,200ug/kg (0.2mg/kg),Drug Safety. Vol. 7, Pg. 387, 1992.