KU-55933 (ATM Kinase Inhibitor) , ≥98% , 587871-26-9

CAS NO.：587871-26-9

Empirical Formula: C21H17NO3S2

Molecular Weight: 395.49

MDL number: MFCD08276985

PRODUCT Properties

• Boiling point: 628.0±55.0 °C(Predicted)
• Density: 1.419±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
• pka: 0.33±0.20(Predicted)
• form: powder
• color: white to beige
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
• InChI: InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
• InChIKey: XRKYMMUGXMWDAO-UHFFFAOYSA-N
• SMILES: C1(N2CCOCC2)OC(C2=C3C(SC4=C(S3)C=CC=C4)=CC=C2)=CC(=O)C=1

Description and Uses

Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1?levels?in vitro.2?Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3?Sensitizes radio-resistant cancer cells.4Provides neuroprotection against H2O2-induced cell damage.5

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3