A5287212
Lomeguatrib , 98% , 192441-08-0
Synonym(s):
2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine;O6-(4-bromothenyl)guanine
CAS NO.：192441-08-0
Empirical Formula: C10H8BrN5OS
Molecular Weight: 326.17
MDL number: MFCD23703756
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB827.20 | In Stock |
|
| 50MG | RMB3740.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 683.8±65.0 °C(Predicted) |
| Density | 2.07 |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 9.42±0.10(Predicted) |
| form | powder |
| color | white to beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | 1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16) |
| InChIKey | JUJPKFNFCWJBCX-UHFFFAOYSA-N |
| SMILES | Nc1nc(OCc2cc(Br)cs2)c3nc[nH]c3n1 |
Description and Uses
Lomeguatrib (192441-08-0) is a potent (IC50= 9 nM) inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein.1It is currently being investigated in cancers that have acquired resistant to the chemotherapeutic temozolomide2-5, as well as other chemotherapeutics6,7.
Lomeguatrib is an inhibitor of O6-methylguanine-DNA methyltransferase (MGMT). Lomeguatrib attenuates MGMT activity in vitro and in vivo. Lomeguatrib enhances the antitumor activity of temozolomide in both human melanoma and MCF-7 xenografts.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| RTECS | UO7420000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
