LY-411575 , ≥98% , 209984-57-6

Synonym(s):
LSN-411575;LY 411575;N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide

CAS NO.：209984-57-6

Empirical Formula: C26H23F2N3O4

Molecular Weight: 479.48

MDL number: MFCD09832551

PRODUCT Properties

• Boiling point: 836.0±65.0 °C(Predicted)
• Density: 1.40
• storage temp.: -20°C
• solubility: DMSO: soluble5mg/mL, clear
• form: powder
• pka: 11.79±0.20(Predicted)
• color: white to beige
• InChIKey: ULSSJYNJIZWPSB-CVRXJBIPSA-N

Description and Uses

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC₅₀ = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29337900