LY2603618 , ≥98% , 911222-45-2

CAS NO.：911222-45-2

Empirical Formula: C18H22BrN5O3

Molecular Weight: 436.3

MDL number: MFCD18633253

PRODUCT Properties

• Boiling point: 503.1±50.0 °C(Predicted)
• Density: 1.461
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 10 mg/ml)
• form: solid
• pka: 12.06±0.70(Predicted)
• color: Off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChI: 1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25)/t13-/m0/s1
• InChIKey: SYYBDNPGDKKJDU-ZDUSSCGKSA-N
• SMILES: N(C1=CC(Br)=C(C)C=C1OC[C@H]1OCCNC1)C(NC1=NC=C(C)N=C1)=O

Description and Uses

LY2603618 (911222-45-2) is a potent (IC50?= 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1?Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4?LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells?via?Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5

LY2603618 is a selective Chk1 inhibitor that can treat idiopathic pulmonary fibrosis.

Safety

• WGK Germany: WGK 3
• HS Code: 29349990
• Storage Class: 11 - Combustible Solids