5-Methyluridine , 99% , 1463-10-1

Synonym(s):
Ribothymidine

CAS NO.：1463-10-1

Empirical Formula: C10H14N2O6

Molecular Weight: 258.23

MDL number: MFCD00006535

EINECS: 215-973-9

PRODUCT Properties

• Melting point: 183-184 °C(lit.)
• Density: 1.576±0.06 g/cm3(Predicted)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Methanol (Slightly, Heated, Sonicated), Water (Sparingly, Sonicated)
• pka: 9.55±0.10(Predicted)
• form: powder
• color: white
• PH: 9.7
• optical activity: -8.9°(C=1 g/100ml H2O)
• λmax: 267 (pH 1)；268 (pH 13)
• InChI: InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1
• InChIKey: DWRXFEITVBNRMK-JXOAFFINSA-N
• SMILES: OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](O)[C@@H]1O
• CAS DataBase Reference: 1463-10-1(CAS DataBase Reference)

Description and Uses

5-Methyluridine is a pyrimidine nucleoside and methylated form of uridine. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is an endogenous methylated nucleoside found in human fluids. In cells, 5-methyluridine is present in tRNA, formed during its post-transcriptional modification by the methylation of uridine.

A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.
It enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model. It has been used to characterize the activity of a variety of enzymes, including uridine nucleosidase.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: T+
• Risk Statements: 26/27/28
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29349990