1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione , >98.0% , 70356-09-1

Synonym(s):
1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione;Butyl methoxydibenzoylmethane

CAS NO.：70356-09-1

Empirical Formula: C20H22O3

Molecular Weight: 310.39

MDL number: MFCD00210252

EINECS: 274-581-6

PRODUCT Properties

• Melting point: 81-84 °C
• Boiling point: 463.6±35.0 °C(Predicted)
• Density: 1.079
• vapor pressure: 0Pa at 25℃
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
• pka: 9.74±0.13(Predicted)
• form: Solid
• color: White to Pale Yellow
• Water Solubility: 27μg/L at 20℃
• λmax: 356nm(EtOH)(lit.)
• Merck: 14,888
• Major Application: cleaning products; cosmetics; environmental; food and beverages; personal care
• Cosmetics Ingredients Functions: LIGHT STABILIZER; UV ABSORBER; UV FILTER
• InChI: 1S/C20H22O3/c1-20(2,3)16-9-5-14(6-10-16)18(21)13-19(22)15-7-11-17(23-4)12-8-15/h5-12H,13H2,1-4H3
• InChIKey: GTIRDWBOUTYFQO-UHFFFAOYSA-N
• SMILES: COc1ccc(cc1)C(=O)CC(=O)c2ccc(cc2)C(C)(C)C
• LogP: 6.1 at 20℃
• CAS DataBase Reference: 70356-09-1(CAS DataBase Reference)
• EPA Substance Registry System: 1,3-Propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)- (70356-09-1)

Description and Uses

Avobenzone is a full-spectrum ultraviolet A (UVA) blocker. It inhibits UVA-induced increases in melanin levels and tyrosinase activity in B16/F10 melanoma cells (IC₃₀s = 21.94 and 24.25 μM, respectively). Avobenzone (30 μM) also inhibits UVA-induced production of reactive oxygen species (ROS) and 8-hydroxy-2''-deoxyguanosine (8-OH-dG; ), as well as inhibits UVA-induced depletion of glutathione (GSH; ), in B16/F10 cells. It increases nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulates the antioxidant response element (ARE) in UVA-irradiated B16/F10 cells when used at at a concentration of 30 μM. Formulations containing avobenzone have been used as a sun protectant in sunscreen products.

avobenzone (BMDM, butyl methoxydibenzoylmethane) is a sun-A screen chemical that offers broad-range protection against uVA rays. It is associated with some photoinstability, which can be overcome in the overall sunscreen formulation. It is approved for use up to 3 percent in the united States and 5 percent in the european union. Avobenzone is noted to rarely be photosensitizing.

Safety

• Symbol(GHS): GHS09
• Signal word: Warning
• Hazard statements: H413
• Precautionary statements: P273-P501
• PPE: Eyeshields, Gloves
• Hazard Codes: N
• Risk Statements: 50/53
• Safety Statements: 60-61
• RIDADR: UN3077 9/PG 3
• WGK Germany: 2
• TSCA: TSCA listed
• HS Code: 29145000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Aquatic Chronic 4
• Hazardous Substances Data: 70356-09-1(Hazardous Substances Data)