2-Methyl-4-isothiazolin-3-one(MIT) , 95% , 2682-20-4

Synonym(s):
2-Methyl-3(2H)-isothiazolone

CAS NO.：2682-20-4

Empirical Formula: C4H5NOS

Molecular Weight: 115.15

MDL number: MFCD00013254

EINECS: 220-239-6

PRODUCT Properties

• Melting point: 254-256 °C(lit.)
• Boiling point: bp0.03 93°
• Density: 1.25 (14% aq.)
• vapor pressure: <0.1 mm Hg ( 25 °C)
• storage temp.: 2-8°C
• solubility: Chloroform, Ethyl Acetate
• form: Solid
• pka: -2.03±0.20(Predicted)
• color: Yellow
• Water Solubility: 489g/L at 20℃
• BRN: 606203
• InChIKey: BEGLCMHJXHIJLR-UHFFFAOYSA-N
• LogP: -0.486 at 20℃
• CAS DataBase Reference: 2682-20-4(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-isothiazolone, 2-methyl-(2682-20-4)
• EPA Substance Registry System: 2-Methyl-3(2H)-isothiazolone (2682-20-4)

Description and Uses

2-Methyl-4-isothiazolin-3-one (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI). MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone. MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 μM and inhibits Src family kinases in cell-free assays. MI, alone and as a mixture with MCI, can elicit contact sensitization.

Methylisothiazolinone is a preservative compound widely used in cosmetics. It is a contact allergen and sensitiser. Methylisothiazolinone has recently been identified as a neurotoxin that can damage nerve endings with repeated exposure.

Safety

• Symbol(GHS): GHS05,GHS06,GHS09
• Signal word: Danger
• Hazard statements: H301+H311-H314-H317-H330-H410
• Precautionary statements: P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
• Hazard Codes: N,C,T
• Risk Statements: 50/53-50-43-34-20/21/22-37-23-22
• Safety Statements: 60-61-36/37/39-26-24-45
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 2
• RTECS: FE1250000
• HazardClass: 8
• PackingGroup: III
• HS Code: 29349990
• Hazardous Substances Data: 2682-20-4(Hazardous Substances Data)