3-(4-Methyl-1<i>H</i>-imidazol-1-yl)-5-(trifluoromethyl)aniline , >98.0% , 641571-11-1

Synonym(s):
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

CAS NO.：641571-11-1

Empirical Formula: C11H10F3N3

Molecular Weight: 241.21

MDL number: MFCD11846236

EINECS: 688-269-6

PRODUCT Properties

• Melting point: 124-126°C
• Boiling point: 372.14℃[at 101 325 Pa]
• Density: 1.35
• vapor pressure: 0Pa at 25℃
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: powder to crystal
• color: White to Light gray to Light yellow
• Water Solubility: 228.6mg/L at 25℃
• InChI: InChI=1S/C11H10F3N3/c1-7-5-17(6-16-7)10-3-8(11(12,13)14)2-9(15)4-10/h2-6H,15H2,1H3
• InChIKey: WWTGXYAJVXKEKL-UHFFFAOYSA-N
• SMILES: C1(N2C=C(C)N=C2)C=C(N)C=C(C(F)(F)F)C=1
• LogP: 2.42
• CAS DataBase Reference: 641571-11-1(CAS DataBase Reference)

Description and Uses

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a pharmaceutical intermediate component used in the preparation of Nilotinib for the treatment of a variety of leukaemias, including chronic myeloid leukaemia (CML).

Intermediate in the preparation of Nilotinib.

Safety

• Symbol(GHS): GHS05,GHS06
• Signal word: Danger
• Hazard statements: H301-H318
• Precautionary statements: P280-P301+P310-P305+P351+P338
• Risk Statements: 41
• Safety Statements: 26-39
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: Ⅲ
• HS Code: 2933299090