Nutlin-3 , ≥98% , 548472-68-0

Synonym(s):
(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one;MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem;MDM2 Inhibitor IV

CAS NO.：548472-68-0

Empirical Formula: C30H30Cl2N4O4

Molecular Weight: 581.49

MDL number: MFCD07784509

EINECS: 200-258-5

PRODUCT Properties

• Melting point: >132oC (dec.)
• Density: 1.36±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMSO: 20 mg/mL, soluble
• form: solid
• pka: 14.35±0.20(Predicted)
• color: White
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
• InChIKey: BDUHCSBCVGXTJM-UHFFFAOYSA-N
• SMILES: N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]2C2=CC=C(Cl)C=C2)=O)CC1=O |&1:20,28,r|

Description and Uses

(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.

(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3