NVP-AUY922 , ≥98% , 747412-49-3

CAS NO.：747412-49-3

Empirical Formula: C26H31N3O5

Molecular Weight: 465.54

MDL number: MFCD14635361

PRODUCT Properties

• Melting point: 180-184°C
• Boiling point: 640.1±55.0 °C(Predicted)
• Density: 1.234
• storage temp.: -20°C
• solubility: Soluble in DMSO (>25 mg/ml)
• pka: 8.47±0.48(Predicted)
• form: solid
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
• InChIKey: NDAZATDQFDPQBD-UHFFFAOYSA-N
• SMILES: O=C(C1=NOC(C2=C(O)C=C(O)C(C(C)C)=C2)=C1C3=CC=C(CN4CCOCC4)C=C3)NCC
• CAS DataBase Reference: 747412-49-3

Description and Uses

Hsp90 is a molecular chaperone of many different kinases, transcription factors, and hormone receptors involved in signal transduction, cell cycle regulation, and apoptosis. In addition to its important function in normal cell homeostasis, a high affinity form of Hsp90 is prevalent in tumor cells. Hsp90 inhibition has been associated with the degradation of oncogenic client proteins. NVP-AUY922 is a Hsp90 inhibitor (IC₅₀ = 21 nM in a FP binding assay) that prevents the proliferation of a range of human cancer cell lines in vitro with GI₅₀s averaging 9 nM. In a human colon cancer xenograft model, 50 mg/kg NVP-AUY922 inhibits tumor growth by ~50% compared to vehicle controls. Unlike some first generation Hsp90 inhibitors that are quickly glucuronidated, NVP-AUY922 is retained in tumors in vivo when administered at 4 mg/kg i.p. by cassette dosing in tumor-bearing mice.

NVP-AUY 922 is a potent inhibitor of heat shock protein 90 (Hsp90) that prevents the proliferation of a range of human cancer cell lines. NVP-AUY 922 has been shown to enhance the radiation sensitivity of tumor cell lines under hypoxia. Potent Hedgehog inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P271-P280
• WGK Germany: WGK 3
• HS Code: 2934999090
• Storage Class: 11 - Combustible Solids