Nicorandil , ≥98%(HPLC) , 65141-46-0

Synonym(s):
2-(Pyridine-3-carbonylamino)ethyl nitrate;2-Nicotinamidoethyl nitrate;Ikorel;N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide;SG-75

CAS NO.：65141-46-0

Empirical Formula: C8H9N3O4

Molecular Weight: 211.17

MDL number: MFCD00186520

EINECS: 265-514-1

PRODUCT Properties

• Melting point: 92°C
• Boiling point: 350.85°C (rough estimate)
• Density: 1.4271 (rough estimate)
• refractive index: 1.7400 (estimate)
• RTECS: US4667600
• storage temp.: 2-8°C
• solubility: DMSO: >10mg/mL
• pka: 12.70±0.46(Predicted)
• form: powder
• color: white to off-white
• Merck: 14,6521
• InChI: InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
• InChIKey: LBHIOVVIQHSOQN-UHFFFAOYSA-N
• SMILES: C1=NC=CC=C1C(NCCO[N+]([O-])=O)=O
• CAS DataBase Reference: 65141-46-0

Description and Uses

Nicorandil is a vasodilator used for the prophylaxis and treatment of angina. This medication widens blood vessels thus increasing the blood and oxygen flow to the heart. It is not currently available in the US.
Nicorandil is a nitric oxide donor and ATP-sensitive potassium channel opener. A study showed that Nicorandil is able to protect against stress-induced cell death in dystrophin-deficient cardiomyocytes and also preserve cardiac function in the mdx mouse heart subjected to ischemia and reperfusion injury.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H242-H302
• Precautionary statements: P210-P235-P280-P301+P312-P370+P378-P410
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xn
• Risk Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• HS Code: 29333990
• Storage Class: 5.2 - Organic peroxides and self-reacting hazardous materials
• Hazard Classifications: Acute Tox. 4 Oral; Org. Perox. D
• Toxicity: LD50 in rats (mg/kg): 1200-1300 orally; 800-1000 i.v. (Nagano)