4-Nitrophenylboronic Acid (contains varying amounts of Anhydride) , ≥95.0% , 24067-17-2

Synonym(s):
p-nitro-benzeneboronic acid;p-Nitrophenylboronic acid;4-Nitrobenzeneboronic acid

Update time: 2022-07-08

Melting point:	285-290°C (dec.)
Boiling point:	373.7±44.0 °C(Predicted)
Density	1.40±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMF: 15 mg/ml; DMSO: 15 mg/ml; Ethanol: 15 mg/ml; Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml
form	Crystalline Powder
pka	7.04±0.10(Predicted)
color	White to yellow
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C6H6BNO4/c9-7(10)5-1-3-6(4-2-5)8(11)12/h1-4,9-10H
InChIKey	NSFJAFZHYOAMHL-UHFFFAOYSA-N
SMILES	B(C1=CC=C([N+]([O-])=O)C=C1)(O)O
CAS DataBase Reference	24067-17-2(CAS DataBase Reference)

4-Nitrobenzeneboronic acid is an arylboronic acid building block that has been used in the synthesis of phenols.

Reagent used for

Ligand-free palladium-catalyzed Suzuki-Miyaura cross-couplings
Ruthenium catalyzed direct arylation of benzylic sp³ carbons of acyclic amines
Diels-Alder or C-H activation reactions
Regioselective Suzuki-Miyaura coupling and tandem palladium-catalyzed intramolecular aminocarbonylation and annulations
N-arylation of phenylurea using copper acetylacetonate catalyst
Environmentally benign one-pot synthesis through a double arylation process
Copper-mediated cyanations
copper-catalyzed arylations
Regioselective glycosylations
Suzuki couplings followed by arylations
X-ray absorption on rhodium-grafted hydrotalcite catalyst for heterogeneous 1,4-addition reaction of organoboron reagents to electron deficient olefins

Reagent used in Preparation of

Combretastatin analogs as potential antitumor agents
Human immunodeficiency virus (HIV) protease inhibitors with antiviral activities against drug-resistant viruses