Obatoclax Mesylate , ≥97% , 803712-79-0

CAS NO.：803712-79-0

Empirical Formula: C20H19N3O.CH4O3S

Molecular Weight: 413.49

MDL number: MFCD18074508

EINECS: 804-325-6

PRODUCT Properties

• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 5 mg/ml).
• form: solid
• color: Purple
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
• InChI: 1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21-22H,1-3H3;1H3,(H,2,3,4)/b19-10-
• InChIKey: ZFKXDVMHNXPEIY-PEZBNFGJSA-N
• SMILES: O=S(O)(C)=O.CC1=C(NC(C)=C1)/C=C2N=C(C3=CC4=C(N3)C=CC=C4)C=C\2OC

Description and Uses

Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells.

Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H315-H301
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501
• WGK Germany: WGK 3
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Acute Tox. 3 Oral; Skin Irrit. 2