Orientin , ≥97%(HPLC) , 28608-75-5
Synonym(s):
8-β-D -Glucopyranosyl-3′,4′,5,7-tetrahydroxyflavone;Luteolin 8-C-β-D -glucopyranoside;Luteolin-8-glucoside;Lutexin
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB639.20 | In Stock |
|
| 25MG | RMB1584.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 260-285°C |
| Boiling point: | 816.1±65.0 °C(Predicted) |
| Density | 1.759±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | 1 M NaOH: soluble1mg/mL, clear, yellow-orange |
| pka | 6.24±0.40(Predicted) |
| form | powder |
| color | yellow |
| Stability: | Hygroscopic |
| InChIKey | PLAPMLGJVGLZOV-FYNBPVOANA-N |
| SMILES | C12OC(=CC(=O)C=1C(=CC(O)=C2[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)O)C1C=CC(O)=C(O)C=1 |&1:12,13,15,16,18,r| |
| LogP | 1.580 (est) |
Description and Uses
Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; ) radicals with an IC50 value of 316.21 μg/ml. It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC50 value of 11.7 μg/ml and a cytotoxic concentration (CC50) value of 375 μg/ml in Hep-2 cells. Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs). It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration.
Orientin is a flavone, a chemical flavonoid compound. Orientin have been investigated for its anti-oxidant, antihypertensive and antihyperlipidemic effects.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | DJ3009300 |
| HS Code | 29389090 |
