Puromycin aminonucleoside , 98% , 58-60-6
Synonym(s):
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
CAS NO.：58-60-6
Empirical Formula: C12H18N6O3
Molecular Weight: 294.31
MDL number: MFCD00063462
EINECS: 200-388-3
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB431.20 | In Stock |
|
| 25MG | RMB1332.80 | In Stock |
|
| 100MG | RMB4799.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 235℃ (Decomposition) |
| Boiling point: | 436.08°C (rough estimate) |
| Density | 1.2131 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| Flash point: | >110°(230°F) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL, clear, slightly yellow |
| form | liquid |
| pka | 13.26±0.70(Predicted) |
| color | White |
| Water Solubility | Soluble in water at 50mg/ml. May require heating |
| BRN | 93902 |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
| InChI | 1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1 |
| InChIKey | RYSMHWILUNYBFW-GRIPGOBMSA-N |
| SMILES | CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O |
| EPA Substance Registry System | Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6) |
Description and Uses
Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1?It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.
Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H373 |
| Precautionary statements | P260-P314-P501a |
| target organs | Kidney |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xi,Xn |
| Risk Statements | 48/22 |
| WGK Germany | 3 |
| RTECS | AU7337000 |
| F | 10-21 |
| TSCA | TSCA listed |
| HS Code | 29419090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | STOT RE 2 |
