Puromycin aminonucleoside , 98% , 58-60-6

Synonym(s):
3′-Amino-3′-deoxy-N⁶,N⁶-dimethyladenosine

CAS NO.：58-60-6

Empirical Formula: C12H18N6O3

Molecular Weight: 294.31

MDL number: MFCD00063462

EINECS: 200-388-3

PRODUCT Properties

• Melting point: 235℃ (Decomposition)
• Boiling point: 436.08°C (rough estimate)
• Density: 1.2131 (rough estimate)
• refractive index: 1.7000 (estimate)
• Flash point: >110°(230°F)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: H₂O: 50 mg/mL, clear, slightly yellow
• pka: 13.26±0.70(Predicted)
• form: liquid
• color: White
• Water Solubility: Soluble in water at 50mg/ml. May require heating
• BRN: 93902
• Stability: Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
• InChI: 1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1
• InChIKey: RYSMHWILUNYBFW-GRIPGOBMSA-N
• SMILES: CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O
• EPA Substance Registry System: Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6)

Description and Uses

Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.

Puromycin Aminonucleoside is an aminonucleoside portion of the antibiotic puromycin.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H373
• Precautionary statements: P260-P314-P501a
• target organs: Kidney
• PPE: Eyeshields, Gloves, type N95 (US)
• Hazard Codes: Xi,Xn
• Risk Statements: 48/22
• WGK Germany: 3
• RTECS: AU7337000
• F: 10-21
• TSCA: TSCA listed
• HS Code: 29419090
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: STOT RE 2