trans-Platinum diammine dichloride , Pt≥64.5% , 14913-33-8

Synonym(s):
trans-Diamminedichloroplatinum(II);trans-Dichlorodiammineplatinum(II);trans-Platinum(II)diammine dichloride

CAS NO.：14913-33-8

Empirical Formula: Cl2H4N2Pt

Molecular Weight: 298.03

MDL number: MFCD00011623

EINECS: 238-980-9

PRODUCT Properties

• Melting point: 340 °C (dec.)(lit.)
• storage temp.: 2-8°C
• solubility: DMSO (Sparingly)
• form: crystalline
• pka: 5.63
• color: yellow
• Water Solubility: Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water.
• Exposure limits: ACGIH: TWA 0.002 mg/m3; NIOSH: IDLH 4 mg/m3; TWA 0.002 mg/m3
• Major Application: pharmaceutical (small molecule)
• InChI: InChI=1S/2ClH.2H2N.Pt/h2*1H;2*1H2;/q;;2*-1;+4/p-2
• InChIKey: DQLATGHUWYMOKM-UHFFFAOYSA-L
• SMILES: [Pt+2](N)(N)([Cl-])[Cl-]
• EPA Substance Registry System: Platinum, diamminedichloro-, (SP-4-1)- (14913-33-8)

Description and Uses

Transplatin is the trans stereoisomer impurity of trans-Dichlorodiamineplatinum(II), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.

Safety

• Symbol(GHS): GHS05,GHS08
• Signal word: Danger
• Hazard statements: H317-H318-H334
• Precautionary statements: P280-P302+P352-P305+P351+P338+P310
• Hazard Codes: T,Xn
• Risk Statements: 45-25-41-68-42/43-40-23/24/25
• Safety Statements: 53-26-39-45-36/37-24-23
• RIDADR: UN 3288 6.1/PG 2
• WGK Germany: 3
• RTECS: TP2455000
• F: 10-21
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 28439000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
• Hazardous Substances Data: 14913-33-8(Hazardous Substances Data)
• Toxicity: mouse,LD50,intraperitoneal,27mg/kg (27mg/kg),Chemico-Biological Interactions. Vol. 5, Pg. 415, 1972.