A6726612
Picropodophyllotoxin , Analysis of standard products, ≥98% , 477-47-4
Synonym(s):
(−)PPP;IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem;Insulin-like Growth Factor-1 Receptor Inhibitor, Picropodophyllin
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB639.20 | In Stock |
|
| 50MG | RMB2319.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 225-227℃ |
| alpha | D20 +9.4° (c = 0.7 in chloroform) |
| Boiling point: | 453.31°C (rough estimate) |
| Density | 1.370 |
| refractive index | 1.4480 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | H2O: soluble |
| form | powder |
| pka | 13.26±0.40(Predicted) |
| color | white |
| Water Solubility | H2O: soluble |
| λmax | 208 nm (in deoxygenated water)(lit.) |
| Sensitive | Light Sensitive |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| InChIKey | YJGVMLPVUAXIQN-HAEOHBJNSA-N |
| SMILES | O1C2=CC3=C(C=C2OC1)[C@@H](C1=CC(OC)=C(OC)C(OC)=C1)[C@]1([H])C(=O)OC[C@]1([H])[C@H]3O |
Description and Uses
Picropodophyllotoxin (477-47-4) is a potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP.1?Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM.1?Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 – 15 μM.2 Exhibits antiangiogenic activity.3?Picropodophyllotoxin attenuates intimal hyperplasia after vascular injury.4?Active in vivo.
Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301-H312-H315-H319-H335 |
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352+P312-P305+P351+P338 |
| target organs | Respiratory system |
| Hazard Codes | Xi,T |
| Risk Statements | 36/37/38-68-25-21 |
| Safety Statements | 26-36-45-36/37 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | LV2510000 |
| HazardClass | 6.1 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Acute Tox. 4 Dermal Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Toxicity | LD50 intraperitoneal in mouse: 280mg/kg |
