Praziquantel , Analysis standard , 55268-74-1

Synonym(s):
2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one;Praziquantel

CAS NO.：55268-74-1

Empirical Formula: C19H24N2O2

Molecular Weight: 312.41

MDL number: MFCD00058531

EINECS: 259-559-6

PRODUCT Properties

• Melting point: 136-138 C
• Boiling point: 1377℃
• Density: 1.1209 (rough estimate)
• refractive index: 1.5600 (estimate)
• Flash point: >110°(230°F)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: ethanol: soluble5mg/mL
• form: powder or crystals
• pka: -0.98±0.20(Predicted)
• color: Crystals from EtOAc/hexane
• Water Solubility: Freely soluble in ethanol or dichloromethane. Slightly soluble in water
• Merck: 13,7802
• BRN: 761557
• BCS Class: 2
• Major Application: clinical testing
• InChI: 1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
• InChIKey: FSVJFNAIGNNGKK-UHFFFAOYSA-N
• SMILES: O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4
• EPA Substance Registry System: Praziquantel (55268-74-1)

Description and Uses

Praziquantel (PZQ) is an isoquinoline derivative with most of the biological activity found in the levo enantiomer. The compound has no activity against nematodes, but it is highly effective against cestodes and trematodes.

Praziquantel is a potent anthelmintic used against schistosome and many cestode infestations. It is used to study voltage-gated Ca2+ channels and is a potential small molecule neurogenic.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H412
• Precautionary statements: P273
• PPE: Eyeshields, Gloves, type N95 (US)
• Hazard Codes: F,C
• Risk Statements: 11-34
• Safety Statements: 16-26-36/37/39-45-24/25
• WGK Germany: 1
• RTECS: UQ4150000
• HS Code: 29339900
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Aquatic Chronic 3
• Toxicity: LD50 in mice, rats (mg/kg): 2000-3000 orally; >3000 s.c. (Muermann)