Phentolamine Mesylate , ≥98.0%(TLC) , 65-28-1

Synonym(s):
2-(N-[m-Hydroxyphenyl]-p-toluidinomethyl)imidazoline;Phentolamine methanesulfonate salt

CAS NO.：65-28-1

Empirical Formula: C18H23N3O4S

Molecular Weight: 377.46

MDL number: MFCD00134201

EINECS: 200-604-6

PRODUCT Properties

• Melting point: 180-182 °C(lit.)
• Density: 1.2256 (rough estimate)
• refractive index: 1.6320 (estimate)
• storage temp.: 2-8°C
• solubility: ethanol: 26 mg/mL
• form: powder
• color: white to off-white
• Water Solubility: 50 mg/mL
• Merck: 14,7264
• Stability: Aq. Solutions Cannot be Stored
• InChI: InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
• InChIKey: OGIYDFVHFQEFKQ-UHFFFAOYSA-N
• SMILES: N(CC1=NCCN1)(C1C=CC(C)=CC=1)C1C=CC=C(O)C=1.S(=O)(=O)(O)C

Description and Uses

Phentolamine mesilate is an adrenergic blocking agent and antihypertensive. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• target organs: Respiratory system
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• RIDADR: 3249
• WGK Germany: 3
• RTECS: SL5430000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29332900
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral; Eye Irrit. 2; Skin Irrit. 2; STOT SE 3
• Toxicity: LDLo scu-rat: 275 mg/kg NIIRDN 6,667,82