Pyrilamine Maleate Salt , 98% , 59-33-6
Synonym(s):
Mepyramine maleate salt;N-(4-Methoxyphenyl)methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt;Pyrilamine maleate salt
CAS NO.：59-33-6
Empirical Formula: C21H27N3O5
Molecular Weight: 401.46
MDL number: MFCD00069333
EINECS: 200-422-7
| Pack Size | Price | Stock | Quantity |
| 1G | RMB55.20 | In Stock |
|
| 5g | RMB168.80 | In Stock |
|
| 25G | RMB551.20 | In Stock |
|
| 100G | RMB1983.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 101-103°C |
| storage temp. | 2-8°C |
| solubility | Very soluble in water, freely soluble in ethanol (96 per cent). |
| form | Solid |
| color | White |
| Water Solubility | Soluble in water at 100mg/ml |
| λmax | 310nm(EtOH)(lit.) |
| Merck | 14,7984 |
| Stability: | Stability Combustible. Incompatible with strong oxidizing agents. |
| Major Application | pharmaceutical (small molecule) |
| InChI | 1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | JXYWFNAQESKDNC-BTJKTKAUSA-N |
| SMILES | OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1 |
| LogP | 2.751 (est) |
| CAS DataBase Reference | 59-33-6(CAS DataBase Reference) |
| EPA Substance Registry System | Pyrilamine maleate (59-33-6) |
Description and Uses
Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H1 receptor. It is reported to bind with high affinity to a Gq/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC50 value of -7.94.
Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| RTECS | UT1225000 |
| TSCA | TSCA listed |
| HS Code | 2933399090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Toxicity | LD50 orally in mice: 338 mg/kg (Hunziker) |
