4,4-Pentamethylene-2-pyrrolidone , >98.0%(GC) , 64744-50-9

Synonym(s):
3-Azaspiro[4.5]decan-2-one;4,4-Pentamethylene-2-pyrrolidinone;4,4-PENTAMETHYLENE-2-PYRROLIDONE;Gabapentin Impurity A

CAS NO.：64744-50-9

Empirical Formula: C9H15NO

Molecular Weight: 153.22

MDL number: MFCD00177938

EINECS: 451-630-1

PRODUCT Properties

• Melting point: 84-89 °C(lit.)
• Boiling point: 181 °C / 13mmHg
• Density: 1.05±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 40 mg/ml)
• pka: 16.39±0.20(Predicted)
• form: solid
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
• InChIKey: JAWPQJDOQPSNIQ-UHFFFAOYSA-N
• CAS DataBase Reference: 64744-50-9(CAS DataBase Reference)

Description and Uses

Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4

Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H319
• Precautionary statements: P261-P280-P305+P351+P338
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: CM0120000
• HazardClass: IRRITANT
• HS Code: 29337900