Pentoxifylline , >98.0% , 6493-05-6

Synonym(s):
3,7-Dimethyl-1-(5-oxohexyl)xanthine;Trental

CAS NO.：6493-05-6

Empirical Formula: C13H18N4O3

Molecular Weight: 278.31

MDL number: MFCD00063379

EINECS: 229-374-5

PRODUCT Properties

• Melting point: 98-100°C
• Boiling point: 421.13°C (rough estimate)
• Density: 1.1713 (rough estimate)
• refractive index: 1.6000 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• solubility: H₂O: ≥43 mg/mL
• pka: 0.50±0.70(Predicted)
• form: solid
• color: white
• Water Solubility: H2O: ≥43mg/mL, colorless to almost colorless
• λmax: 276nm(lit.)
• Merck: 14,7136
• Major Application: pharmaceutical (small molecule)
• InChI: 1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3
• InChIKey: MQGNNJQTNFHNHK-UHFFFAOYSA-N
• SMILES: CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C
• CAS DataBase Reference: 6493-05-6(CAS DataBase Reference)
• NIST Chemistry Reference: Pentoxifylline(6493-05-6)
• EPA Substance Registry System: 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)- (6493-05-6)

Description and Uses

Pentoxifylline can increase red blood cell deformability, reduce blood viscosity, and decrease platelet aggregation and thrombus formation. Pentoxifylline is an oral agent that improves perfusion of occluded vessels and is used to treat systemic vascular diseases. The retinal flow velocity in patients with RVO treated with pentoxifylline improved compared with placebo, but the study had a small number of patients (n = 8) and short follow-up (4 weeks), and no visual outcome data were reported.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P501-P270-P264-P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: XH2475000
• HS Code: 2939590000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral; Lact.
• Toxicity: LD50 orally in mice: 1385 mg/kg (Popendiker)