DoripenemHydrate , 10mMinDMSO , 364622-82-2
Synonym(s):
(4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
CAS NO.：364622-82-2
Empirical Formula: C15H26N4O7S2
Molecular Weight: 438.51
MDL number: MFCD09749887
EINECS: 680-392-3
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 173°C(dec.)(lit.) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble5mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| PH | Dissolve 0.3g of Doripenem Hydrate in 30mL of water: the pH of the solution is between 4.5 and 6.0. |
| Water Solubility | H2O: 5mg/mL, clear (warmed) |
| BRN | 15340136 |
| InChIKey | NTUBEBXBDGKBTJ-WGLOMNHJSA-N |
| SMILES | C(C1=C([C@H](C)[C@]2([H])[C@@]([H])([C@H](O)C)C(=O)N12)S[C@@H]1CN[C@H](CNS(=O)(=O)N)C1)(=O)O.O |&1:3,5,7,9,16,19,r| |
| CAS DataBase Reference | 364622-82-2(CAS DataBase Reference) |
Description and Uses
Doripenem hydrate is a carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.
Doripenem hydrate was first approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on July 25, 2005, then approved by the U.S. Food and Drug Administration (FDA) on Oct 12, 2007, and approved by European Medicines Agency (EMA) on July 25, 2008. It was developed by Shionogi and Janssen, then marketed as Finibax® in Japan and as Doribax® in the US by Shionogi and as Doribax® by Janssen in BE.
Doripenem (doripenem monohydrate) is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It is particularly active against Pseudomonas aeruginosa
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H341 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| WGK Germany | 3 |
| HS Code | 2935.90.9500 |
| Storage Class | 11 - Combustible Solids |
