BCTC , 10mMinDMSO , 393514-24-4

Synonym(s):
4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide

CAS NO.：393514-24-4

Empirical Formula: C20H25ClN4O

Molecular Weight: 372.89

MDL number: MFCD08690556

PRODUCT Properties

• Melting point: 150-152℃
• Boiling point: 561.6±50.0 °C(Predicted)
• Density: 1.229±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO: >10mg/mL
• pka: 13.95±0.70(Predicted)
• form: powder
• color: white to beige
• Sensitive: Light Sensitive
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stord at -20°C for up to 2 months.
• InChI: InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
• InChIKey: ROGUAPYLUCHQGK-UHFFFAOYSA-N
• SMILES: N1(C(NC2=CC=C(C(C)(C)C)C=C2)=O)CCN(C2=NC=CC=C2Cl)CC1

Description and Uses

BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) blocker, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. BCTC is orally active and cell permeable.

BCTC is a antagonists of TRPA1 and TRPV1, a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons. BCTC inhibits both capsaicin and proton activation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264b-P270-P301+P312-P330-P403-P501c
• Hazard Codes: Xn
• Risk Statements: 22
• WGK Germany: 3