3,4-Dihydroxyhydrocinnamicacid , 10mMinDMSO , 1078-61-1

Synonym(s):
3-(3,4-Dihydroxyphenyl)propionic acid;Hydrocaffeic acid

CAS NO.：1078-61-1

Empirical Formula: C9H10O4

Molecular Weight: 182.17

MDL number: MFCD00002776

EINECS: 214-083-8

PRODUCT Properties

• Melting point: 136-139 °C(lit.)
• Boiling point: 418℃
• Density: 1.398
• Flash point: 220℃
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 4.75±0.10(Predicted)
• color: Pale Beige to Pale Brown
• Water Solubility: Slightly soluble in water.
• BRN: 2213449
• InChI: InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13)
• InChIKey: DZAUWHJDUNRCTF-UHFFFAOYSA-N
• SMILES: C1(CCC(O)=O)=CC=C(O)C(O)=C1
• LogP: 0.115 (est)
• CAS DataBase Reference: 1078-61-1(CAS DataBase Reference)

Description and Uses

Dihydrocaffeic acid is a polyphenol that has diverse biological activities, including antioxidant, neuroprotective, and enzyme inhibitory properties. Dihydrocaffeic acid scavenges ABTS (; IC₅₀ = 81.86 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH; ; IC₅₀ = 192.86 μg/ml) radicals and increases the survival of RGC-5 mouse retinal ganglion cells under hypoxic conditions and in the presence of S-nitroso-N-acetyl-D,L-penicillamine (SNAP; ) in a concentration-dependent manner. It also decreases endothelial nitric oxide synthase (eNOS) activity in EA.hy926 human endothelial cells in a concentration-dependent manner. In vivo, dihydrocaffeic acid (30 mg/kg) decreases infarct size in a rat model of transient ischemia induced by middle cerebral artery occlusion (MCAO).

3-(3,4-Dihydroxyphenyl)propionic acid it can be used to produce 3-(3,4-dihydroxy-phenyl)-propionic acid octyl ester by heating.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: MW5143500