A7014458
CPI203 , 10mMinDMSO , 1446144-04-2
CAS NO.：1446144-04-2
Empirical Formula: C19H18ClN5OS
Molecular Weight: 399.9
MDL number: MFCD27997886
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 690.4±65.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ≥40 mg/mL in DMSO; insoluble in H2O; ≥6.1 mg/mL in EtOH with ultrasonic |
| pka | 16.00±0.40(Predicted) |
| form | powder |
| color | white to beige |
| InChI | 1S/C19H18ClN5OS/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)22-14(8-15(21)26)18-24-23-11(3)25(18)19/h4-7,14H,8H2,1-3H3,(H2,21,26)/t14-/m0/s1 |
| InChIKey | QECMENZMDBOLDR-AWEZNQCLSA-N |
| SMILES | CC1=NN=C2[C@H](CC(N)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(SC(C)=C4C)N21 |
Description and Uses
CPI-203 is a primary amide analog of (+)-JQ1, which has shown superior bioavailability with oral or i.p. administration. CPI-203 downregulates Myc expression, causes G1 cell cycle arrest and attenuates cell proliferation in human pancreatic neuroendocrine tumors. CPI-203 also arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC50 = 91.2 nM).
CPI-203 is a bromodomain and extraterminal domain (BET) inhibitor.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
