EXP3174 , 10mMinDMSO , 124750-92-1
Synonym(s):
2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid;E-3174;EXP 3174;EXP3174;EXP-3174
CAS NO.：124750-92-1
Empirical Formula: C22H21ClN6O2
Molecular Weight: 436.89
MDL number: MFCD00871928
EINECS: 1592732-453-0
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 130-132°C |
| Boiling point: | 707.8±70.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Dimethylformamide, Dimethyl Sulfoxide, Methanol |
| form | Solid |
| pka | 0.79±0.50(Predicted) |
| color | Light-Yellow |
| InChIKey | ZEUXAIYYDDCIRX-UHFFFAOYSA-N |
| SMILES | C1(CCCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C(O)=O)=C(Cl)N=1 |
Description and Uses
Losartan carboxylic acid is a physiologically active metabolite of losartan , produced by cytochrome P450 isoforms in the liver. Like the parent compound, losartan carboxylic acid is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. Losartan, but not its metabolite, inhibits platelet aggregation in vitro.
Losartan carboxylic acid is used as a metabolite of Losartan.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H317-H360D-H362 |
| Precautionary statements | P202-P260-P263-P280-P302+P352-P308+P313 |
| Safety Statements | 24/25 |
| HS Code | 29339900 |
