Ceftizoximesodium , 10mMinDMSO , 68401-82-1

Synonym(s):
Ceftizoxime sodium

CAS NO.：68401-82-1

Empirical Formula: C13H14N5NaO5S2

Molecular Weight: 407.39

MDL number: MFCD01682036

EINECS: 629-729-8

PRODUCT Properties

• Melting point: 227℃
• RTECS: XI0368000
• storage temp.: -20°C
• solubility: DMSO: soluble1mg/mL
• form: solid
• color: white to faint yellow
• Water Solubility: Soluble in water
• Stability: Unstable in Solution
• InChIKey: IYYQWKATOXYCHY-SFXQLROPNA-N
• SMILES: O=C1[C@@H](NC(=O)/C(/C2N=C(N)SC=2)=N\OC)[C@@]2([H])SCC=C(C(=O)O)N12.[NaH] |&1:2,16,r|
• CAS DataBase Reference: 68401-82-1(CAS DataBase Reference)

Description and Uses

Ceftizoxime was synthesized by Fujisawa Pharmaceutical Industries in 1979. It possesses the (iminothiazolyl)methoxyiminomethyl group at the 7 position of the cephem nucleus, but there is no side chain at the 3 position. The compound shows excellent activity against gram-positive and gram-negative bacteria, behavior similar to that of cefotaxime. Unlike cefotaxime, however, it is not metabolized in vivo.

A broad spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Toxicity: LD50 in mice, rats (mg/kg): ~6000 i.v. (Fukuhara)