AminoguanidineHydrochloride , 10mMinDMSO , 1937-19-5

CAS NO.：1937-19-5

Empirical Formula: CH7ClN4

Molecular Weight: 110.546

MDL number: MFCD00039074

EINECS: 217-707-7

PRODUCT Properties

• Melting point: 162-166 °C(lit.)
• vapor pressure: 0Pa at 25℃
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Completely soluble in water
• form: Crystals
• color: White to off-white
• Water Solubility: 506.7g/L at 20℃
• Merck: 13,440
• BRN: 3909606
• InChI: InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
• InChIKey: UBDZFAGVPPMTIT-UHFFFAOYSA-N
• SMILES: N(N)C(=N)N.[H]Cl
• LogP: -3.55 at 20℃
• CAS DataBase Reference: 1937-19-5(CAS DataBase Reference)
• EPA Substance Registry System: Hydrazinecarboximidamide, monohydrochloride (1937-19-5)

Description and Uses

Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC₅₀ values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 μM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages. Aminoguanidine Hydrochloride is used in the synthetic preparation of highly selective and potent G-protein-coupled receptor kinase 2 (GRK2) inhibitor for potential treatment of heart failure.                                                            

antitussive

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H317-H411
• Precautionary statements: P261-P272-P273-P280-P302+P352-P333+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: ME8430000
• F: 10-21
• HS Code: 29280000