PRODUCT Properties
| Melting point: | 208°C |
| Boiling point: | 478.0±45.0 °C(Predicted) |
| Density | 1.258 |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly, Sonicated), Methanol (Slightly) |
| form | Solid |
| pka | 9.43±0.50(Predicted) |
| color | Pale Yellow to Light Yellow |
| InChI | InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) |
| InChIKey | OVCDSSHSILBFBN-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(NC2C3C(N=CC=2)=CC(Cl)=CC=3)C=C1CN(CC)CC |
| CAS DataBase Reference | 86-42-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Amodiaquine(86-42-0) |
Description and Uses
Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine . It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.
An antimalarial
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazardous Substances Data | 86-42-0(Hazardous Substances Data) |
| Toxicity | LD50 oral in mouse: 550mg/kg |
