A7085958
BIO-acetoxime , 10mMinDMSO , 667463-85-6
Synonym(s):
(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime;(3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one;6-Bromoindirubin acetoxime;6-Bromoindirubin-3′-acetoxime;BIA
CAS NO.：667463-85-6
Empirical Formula: C18H12BrN3O3
Molecular Weight: 398.21
MDL number: MFCD09037533
EINECS: 200-258-5
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB381.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Density | 1.69±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | H2O: soluble2mg/mL (clear solution, warmed) |
| form | powder |
| pka | 9.22±0.20(Predicted) |
| color | dark red to purple |
| Water Solubility | H2O: 2mg/mL (clear solution, warmed) |
| InChI | 1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+ |
| InChIKey | MENDIXKFTXYTHJ-HPBPSMLHSA-N |
| SMILES | CC(=O)O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34 |
Description and Uses
BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H410 |
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 |