R406 (free base) , ≥99% , 841290-80-0

Synonym(s):
;Syk Inhibitor VI, R406 - CAS 841290-80-0 - Calbiochem

CAS NO.：841290-80-0

Empirical Formula: C22H23FN6O5

Molecular Weight: 470.45

MDL number: MFCD09970820

EINECS: 617-533-5

PRODUCT Properties

• Melting point: 182-184°C
• Density: 1.358±0.06 g/cm3(Predicted)
• storage temp.: Refrigerator
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 10.63±0.40(Predicted)
• color: Off-White to Light Grey
• InChI: 1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
• InChIKey: NHHQJBCNYHBUSI-UHFFFAOYSA-N
• SMILES: CC1(C(NC2=C(O1)C=CC(NC3=NC(NC4=CC(OC)=C(C(OC)=C4)OC)=NC=C3F)=N2)=O)C

Description and Uses

R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.[Cayman Chemical]

Safety

• Symbol(GHS): GHS08,GHS06
• Signal word: Danger
• Hazard statements: H301-H361
• Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501-P201-P202-P281-P308+P313-P405-P501
• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids