(<i>R</i>)-(-)-1-Methoxy-2-propanol , >96.0%(GC) , 4984-22-9

Synonym(s):
(R)-(−)-Propylene glycol 1-methyl ether

CAS NO.：4984-22-9

Empirical Formula: C4H10O2

Molecular Weight: 90.12

MDL number: MFCD01632587

EINECS: 628-460-3

PRODUCT Properties

• Melting point: -97 °C
• Boiling point: 119-121 °C (lit.)
• Density: 0.921 g/mL at 20 °C (lit.)
• refractive index: n20/D 1.403
• Flash point: 33 °C
• storage temp.: Sealed in dry,2-8°C
• pka: 14.49±0.20(Predicted)
• form: Liquid
• color: Clear colorless
• optical activity: [α]20/D 22±2°, c = 10% in chloroform
• BRN: 1718941
• InChI: InChI=1S/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3/t4-/m1/s1
• InChIKey: ARXJGSRGQADJSQ-SCSAIBSYSA-N
• SMILES: C(OC)[C@H](O)C
• CAS DataBase Reference: 4984-22-9(CAS DataBase Reference)

Description and Uses

(R)-(-)-1-Methoxy-2-propanol can be used as a reactant to prepare:

• (S)-3-(ethoxycarbonyl)-5-((1-methoxypropan-2-yl)oxy)benzoic acid, a key intermediate to synthesize phenylethyl benzamide derivatives, which can be used as glucokinase activators.
• Chiral pyrazolopyrimidinone derivatives as potential phosphodiesterase enzyme (PDE5) inhibitors.
• Aryl or alkyl ethers via etherification reaction.

Safety

• Symbol(GHS): GHS02
• Signal word: Warning
• Hazard statements: H320-H336-H226
• Precautionary statements: P501-P261-P240-P210-P233-P243-P241-P242-P271-P264-P280-P370+P378-P337+P313-P305+P351+P338-P303+P361+P353-P304+P340+P312-P403+P233-P403+P235-P405
• Hazard Codes: F,Xn
• Risk Statements: 10-15
• Safety Statements: 24-43-7/8
• RIDADR: UN 3092 3/PG 3
• WGK Germany: 1
• HazardClass: 3
• PackingGroup: Ⅲ
• HS Code: 29051990