A7324912
Spermine , forcellculture,≥98.0%(GC) , 71-44-3
Synonym(s):
N,N′-Bis(3-aminopropyl)-1,4-diaminobutane;Gerontine;Musculamine;Neuridine
CAS NO.：71-44-3
Empirical Formula: C10H26N4
Molecular Weight: 202.34
MDL number: MFCD00012914
EINECS: 200-754-2
| Pack Size | Price | Stock | Quantity |
| 1G | RMB396.80 | In Stock |
|
| 5G | RMB1594.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 28-30 (lit.) |
| Boiling point: | 150 °C/5 mmHg (lit.) |
| Density | 0.937 |
| refractive index | 1.4850 (estimate) |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| form | powder |
| pka | 10.88±0.19(Predicted) |
| color | Colorless to off-white |
| biological source | microbial synthetic |
| Water Solubility | Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether. |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 14,8743 |
| BRN | 1751791 |
| Stability: | Hygroscopic |
| InChIKey | PFNFFQXMRSDOHW-UHFFFAOYSA-N |
| LogP | -0.543 (est) |
| CAS DataBase Reference | 71-44-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Spermine(71-44-3) |
| EPA Substance Registry System | 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3) |
Description and Uses
Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.
immune modulator
Safety
| Symbol(GHS) |  GHS05 |
| Signal word | Danger |
| Hazard statements | H318-H314 |
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338-P310 |
| Hazard Codes | Xi,C |
| Risk Statements | 36/38-34 |
| Safety Statements | 26-36-45-36/37/39-27 |
| RIDADR | UN 3259 8/PG 2 |
| WGK Germany | 3 |
| RTECS | EJ7230000 |
| F | 3-10 |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29212900 |
