Saikosaponin D from Bupleurum falcatnum , Analysis of standard products, ≥98% , 20874-52-6
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB540.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 212～218℃ |
| Boiling point: | 893.7±65.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, Refrigerator, Under inert atmosphere |
| solubility | Methanol (Slightly), Pyridine (Slightly) |
| form | Solid |
| pka | 12.83±0.70(Predicted) |
| color | White to Off-White |
| Stability: | Hygroscopic |
| InChIKey | KYWSCMDFVARMPN-LPVIBIOGNA-N |
| LogP | 3.756 (est) |
| CAS DataBase Reference | 20874-52-6 |
Description and Uses
Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells. Saikosaponin D is a Glucocorticoid receptor agonist. It is a COX-2 and iNOS inhibitor.
Saikosaponin D is an inhibitor of proliferation of human prostate cancer cells through arresting the cell cycle.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Safety Statements | 24/25 |
| RTECS | VN3099000 |
| HS Code | 29389090 |
