A7364712
Safinamide , ≥98% , 133865-89-1
CAS NO.：133865-89-1
Empirical Formula: C17H19FN2O2
Molecular Weight: 302.34
MDL number: MFCD00897036
EINECS: 603-772-2
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB255.20 | In Stock |
|
| 50MG | RMB1071.20 | In Stock |
|
| 250MG | RMB3831.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 208-212° |
| Boiling point: | 476.7±40.0 °C(Predicted) |
| Density | 1.189±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Soluble in DMSO (up to 50 mg/ml). |
| form | solid |
| pka | 16.03±0.50(Predicted) |
| color | White |
| Merck | 14,8315 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1 |
| InChIKey | NEMGRZFTLSKBAP-LBPRGKRZSA-N |
| SMILES | C(N)(=O)[C@@H](NCC1=CC=C(OCC2=CC=CC(F)=C2)C=C1)C |
Description and Uses
Safinamide (133865-89-1) is a selective and reversible inhibitor of monoamine oxidase B (MAO-B, IC50=98 nM with greater than 100-fold selectivity over MAO-A.1?Displays anticonvulsant activity2?and protects against kainate-induced seizures and hippocampal neurodegeneration in rat models3. Reduces overactive glutamatergic signaling via use-dependent sodium channel blockade.4?A novel therapeutic for Parkinson’s disease with multiple modes of action.5?Effective as an add-on to dopamine agonist therapy in early Parkinson’s.6
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P305+P351+P338 |
| RTECS | TX1457385 |
| HS Code | 2924.29.7790 |
