SB431542 , ≥98% , 301836-41-9

Synonym(s):
4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate;4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate

CAS NO.：301836-41-9

Empirical Formula: C22H16N4O3

Molecular Weight: 384.39

MDL number: MFCD05865244

PRODUCT Properties

• Melting point: 214 °C(dec.)
• Boiling point: 662.4±55.0 °C(Predicted)
• Density: 1.373
• Flash point: 354.4℃
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO: 10 mg/mL, soluble
• form: powder
• pka: 10.14±0.10(Predicted)
• color: Yellow
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• InChI: InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
• InChIKey: FHYUGAJXYORMHI-UHFFFAOYSA-N
• SMILES: C(N)(=O)C1=CC=C(C2NC(C3=NC=CC=C3)=C(C3=CC=C4OCOC4=C3)N=2)C=C1

Description and Uses

SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It is a less potent antagonist of ALK4 (IC₅₀ = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer. Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells. Potent TGF-beta inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P280-P305+P351+P338-P362+P364
• Safety Statements: 22-24/25
• WGK Germany: 3
• HS Code: 29349990