SB705498 , 98% , 501951-42-4

CAS NO.：501951-42-4

Empirical Formula: C17H16BrF3N4O

Molecular Weight: 429.23

MDL number: MFCD13152399

PRODUCT Properties

• Boiling point: 506.9±50.0 °C(Predicted)
• Density: 1.59
• storage temp.: -20°C
• solubility: Soluble in DMSO (>25 mg/ml)
• pka: 13.00±0.20(Predicted)
• form: solid
• color: White
• Stability: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChI: InChI=1S/C17H16BrF3N4O/c18-13-3-1-2-4-14(13)24-16(26)23-12-7-8-25(10-12)15-6-5-11(9-22-15)17(19,20)21/h1-6,9,12H,7-8,10H2,(H2,23,24,26)/t12-/m1/s1
• InChIKey: JYILLRHXRVTRSH-GFCCVEGCSA-N
• SMILES: N(C1=CC=CC=C1Br)C(N[C@@H]1CCN(C2=NC=C(C(F)(F)F)C=C2)C1)=O

Description and Uses

The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin . SB-705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated activation of TRPV1 receptors (pK_is = 7.6, 7.5, and 7.3 for human, rat, and guinea pig, respectively). It has been shown to induce rapid, reversible inhibition of capsaicin (IC₅₀ = 3 nM)-, acid (pH 5.3)-, or heat (50°C; IC₅₀ = 6 nM)-mediated activation of human TRPV1 (at -70 mV).

SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405