Sulfamethizole , 98% , 144-82-1

Synonym(s):
N¹-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide;4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide;Sulfamethizole;Sulfamethylthiadiazole

CAS NO.：144-82-1

Empirical Formula: C9H10N4O2S2

Molecular Weight: 270.33

MDL number: MFCD00053363

EINECS: 205-641-1

PRODUCT Properties

• Melting point: 210 °C
• Boiling point: 176°C (rough estimate)
• Density: 1.4704 (rough estimate)
• refractive index: 1.6440 (estimate)
• storage temp.: 2-8°C
• solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
• pka: 5.45(at 25℃)
• form: Solid
• color: White to Off-White
• Water Solubility: 529mg/L(20 ºC)
• Merck: 14,8916
• BRN: 255002
• Henry's Law Constant: 3.8×10⁸ mol/(m³Pa) at 25℃, HSDB (2015)
• Major Application: clinical testing
• InChI: 1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)
• InChIKey: VACCAVUAMIDAGB-UHFFFAOYSA-N
• SMILES: Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1
• CAS DataBase Reference: 144-82-1(CAS DataBase Reference)
• EPA Substance Registry System: Sulfamethizole (144-82-1)

Description and Uses

Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC₉₀s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae). It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.

Sulfamethizole is a sulfonamide based antibiotic that exhibit bactericidal activities towards gram-negative bacteria. Sulfamehizole was shown to be effective in treating gram-negative Bacillus AmpC en zyme in elderly patients with lower respiratory tract infection and as well as against microbs responsible for tuberculosis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317
• Precautionary statements: P280
• PPE: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 43
• Safety Statements: 36/37
• WGK Germany: 2
• RTECS: WP0875000
• TSCA: TSCA listed
• HS Code: 2935904000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Skin Sens. 1
• Hazardous Substances Data: 144-82-1(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: 3500mg/kg