Swainsonine , ≥98% , 72741-87-8
Synonym(s):
(1S,2R,8R,8aR)-1,2,8-Octahydroindolizidinetriol;(1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol;Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 1MG | RMB1199.20 | In Stock |
|
| 5MG | RMB4319.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 148-149°C |
| Boiling point: | 353.3±21.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | -20°C |
| solubility | H2O: soluble1mg/mL |
| pka | 14.01±0.60(Predicted) |
| form | lyophilized powder |
| color | white to faint yellow |
| biological source | synthetic |
| Water Solubility | Soluble to 50 mM in water |
| BRN | 4175740 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 72741-87-8 |
Description and Uses
Swainsonine (72741-87-8) is a naturally occurring alkaloidal toxin found in locoweed. Inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II (IC50 = 0.2 mM).1 Inhibits growth and potentiates the cytotoxic effect of taxol in hepatocellular carcinoma in vivo.2 Induces apoptosis in a variety of cell types including cerebral cortical neurons.3 Impairs adult neurogenesis and spatial learning and memory.4? Abrogation of complex glycosylation by swainsonine results in strain-and cell-specific inhibition of prion replication.5 Induces lysosomal storage disease in farm animals.6
Swainsonine is a plant alkaloid derived from Swainsona canescens (a leguminous plant). It is a reversible, active-site directed inhibitor of a-mannosidase at concentrations of 5-10mM. At acid pH, swainsonine resembles an intermediate in the hydrolysis of mannosidases.Swainsonine completely inhibits mammalian Golgi a-mannosidase II (a-3/6-mannosidase in the glycoprotein processing pathway) and mammalian lysosomal a-mannosidase (acid mannosidase). At higher concentrations, swainsonine also inhibits mammalian cytosolic a-mannosidase. It has been shown to inhibit growth of transformed fibroblasts in soft agar and to enhance the antiproliferative effects of INF on murine lymphoreticular tumor cells in vitro. It also blocks the expression of b1-6 branched complex-type oligosaccharides and shun
