S-(5&#8242;-Adenosyl)-<SC>L</SC>-homocysteine , ≥98% , 979-92-0

Synonym(s):
5′-Deoxy-S-adenosyl-L-homocysteine;AdoHcy;S-(5′-Adenosyl)-L-homocysteine;S-(5′-Deoxyadenosine-5′)-L-homocysteine

CAS NO.：979-92-0

Empirical Formula: C14H20N6O5S

Molecular Weight: 384.41

MDL number: MFCD00037388

EINECS: 213-560-8

PRODUCT Properties

• Melting point: 209-211 °C
• Boiling point: 787.5±70.0 °C(Predicted)
• Density: 1.91±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: 1 M HCl: soluble19.60 - 20.40mg/mL, clear to slightly hazy, colorless to faintly yellow
• form: crystalline
• pka: 2.22±0.10(Predicted)
• color: Off-White to Brown
• BRN: 99188
• Stability: Hygroscopic
• InChIKey: ZJUKTBDSGOFHSH-WFMPWKQPSA-N
• SMILES: C(O)(=O)[C@H](CCSC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1O)N
• CAS Number Unlabeled: 979-92-0

Description and Uses

S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis. It is also a product of S-adenosyl-methionine (SAM)-dependent methylation of biological molecules, including DNA, RNA, and histones and other proteins. SAH is a risk factor for many diseases, including cancer and neurodegenerative diseases. In addition, inhibitors that block its hydrolysis are being developed as anti-viral, anti-parasitic, anti-arthritic and immunosuppressive agents.

A novel biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder.

Safety

• WGK Germany: 3
• F: 8-10-23
• HS Code: 2934990002