A7475112
Shikonin , 98%(HPLC) , 54952-43-1
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB244.80 | In Stock |
|
| 50MG | RMB682.40 | In Stock |
|
| 250mg | RMB3199.20 | In Stock |
|
| 500mg | RMB5759.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 144-145 °C |
| Boiling point: | 567.4±50.0 °C(Predicted) |
| Density | 1.373±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | methanol: soluble1mg/mL |
| pka | 7.34±0.20(Predicted) |
| form | powder or solid |
| color | red to brown |
| InChI | InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3 |
| InChIKey | NEZONWMXZKDMKF-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C(O)=CC=C2O)C(=O)C=C1C(O)C/C=C(\C)/C |
| LogP | 4.350 (est) |
Description and Uses
Shikonin has been used:
- to enhance the anti-tumor activity of gefitinib on tyrosine kinase receptor epidermal growth factor receptor (EGFR) in wild-type lung cancer cells
- as an inhibitor of renal aerobic glycosis and a potential
- as an anti-inflammatory agent to test its role to improve lipopolysaccharide (LPS)-induced cardiac dysfunction
- to stimulate bone marrow-derived macrophages (BMDMs) to test the effect of Interferon regulatory factor 1 on cell death
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H400 |
| Precautionary statements | P273-P301+P312+P330 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
