Span™ 20 , 100% , 1338-39-2

Synonym(s):
Sorbitan laurate;Sorbitan monolaurate;Sorbitan monolaurate, Sorbitan monododecanoate;Span 20

CAS NO.：1338-39-2

Empirical Formula: C18H34O6

Molecular Weight: 346.46

MDL number: MFCD00005365

EINECS: 215-663-3

PRODUCT Properties

• Boiling point: 401.18°C (rough estimate)
• Density: 1.032 g/mL at 25 °C(lit.)
• vapor pressure: <1.3 hPa (20 °C)
• refractive index: n20/D 1.474(lit.)
• Flash point: >230 °F
• storage temp.: Store below +30°C.
• solubility: Practically insoluble, but dispersible in water, miscible with alcohol.
• form: Liquid
• Specific Gravity: 1.032
• color: Clear amber colour
• Water Solubility: Soluble in 2-ethoxyethanol, ethanol and methanol. Not miscible or difficult to mix in water.
• Merck: 14,8724
• Hydrophilic-Lipophilic Balance (HLB): 8.6
• Cosmetics Ingredients Functions: SURFACTANT - EMULSIFYING
• InChI: 1S/C18H34O6/c1-2-3-4-5-6-7-8-9-10-11-16(21)23-13-15(20)18-17(22)14(19)12-24-18/h14-15,17-20,22H,2-13H2,1H3/t14-,15?,17+,18-/m1/s1
• InChIKey: LWZFANDGMFTDAV-IOVMHBDKSA-N
• SMILES: O1[C@@H]([C@H]([C@@H](C1)O)O)C(O)COC(=O)CCCCCCCCCCC
• LogP: 3.366 (est)
• CAS DataBase Reference: 1338-39-2(CAS DataBase Reference)
• EPA Substance Registry System: Sorbitan monolaurate (1338-39-2)

Description and Uses

Span 20 has been used in a study to assess enhanced solubility and oral bioavailability of itraconazole. It has also been used in a study to investigate the oxidation of unsaturated lipids in oil-in-water emulsions.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H317-H319-H335
• Precautionary statements: P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
• Safety Statements: 24/25
• WGK Germany: 1
• RTECS: WG2920000
• F: 10-23
• TSCA: TSCA listed
• HS Code: 34021300
• Storage Class: 10 - Combustible liquids
• Toxicity: LD50 orally in Rabbit: 33600 mg/kg