Flumethasone , 10mMinDMSO , 2135-17-3
Synonym(s):
6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione;6α,9α-Difluoro-16α-methylprednisolone;6α-Fluorodexamethasone
CAS NO.：2135-17-3
Empirical Formula: C22H28F2O5
Molecular Weight: 410.45
MDL number: MFCD00056464
EINECS: 218-370-9
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 237-240°C |
| Boiling point: | 569.8±50.0 °C(Predicted) |
| Density | 1.1621 (estimate) |
| storage temp. | 2-8°C |
| solubility | acetic acid: soluble10mg/mL |
| pka | 11.98±0.70(Predicted) |
| form | solid |
| color | white |
| optical activity | [α]25/D 67.0 to 71.0°, c = 1 in dioxane |
| Water Solubility | 1mg/L(20 ºC) |
| Merck | 14,4138 |
| InChIKey | WXURHACBFYSXBI-GQKYHHCASA-N |
| SMILES | C1(=O)C=C2[C@](C)(C=C1)[C@]1(F)[C@]([H])([C@@]3([H])[C@@](C[C@@H]1O)(C)[C@@](O)(C(=O)CO)[C@H](C)C3)C[C@@H]2F |
| CAS DataBase Reference | 2135-17-3(CAS DataBase Reference) |
Description and Uses
Flumethasone is an agonist of glucocorticoid and mineralocorticoid receptors with EC50 values of 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors. In vitro, it inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines at a concentration of 100 nM. Flumethasone (5 mg per animal) decreases tumor necrosis factor (TNF) production ex vivo in blood cells collected by bronchoalveolar lavage (BAL) from calves with experimentally-induced local lung inflammation. It also inhibits phytohemagglutinin-induced delayed hypersensitivity in calf skin. In vivo, flumethasone (5 μM) impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in zebrafish.
A glucocorticoid. An anti-inflammatory.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H351 |
| Precautionary statements | P281 |
| PPE | Eyeshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn |
| Risk Statements | 40 |
| Safety Statements | 22-36 |
| WGK Germany | 3 |
| RTECS | TU3832000 |
| HS Code | 29144000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Carc. 2 |
| REACH Registrations | Active |
